Jamian Juliano-Villani is known for her vibrant and chaotic paintings that draw inspiration from a diverse array of sources, including late-night re-run cartoons, music, Japanese drawings, and modernist painting. Juliano-Villani is known for her visually loud compositions, which mash cartoonish figures together with an odd assortment of objects and spaces. These elements create evocative yet nightmarish scenes that spring from her unique imagination. Her signature style is characterized by a bold use of color and a meticulous attention to detail, often resulting in works that are as unsettling as they are intriguing. In addition to her paintings, Juliano-Villani's text-based works also draw heavily on pop culture, further cementing her reputation as an artist who skillfully blends high and low cultural references.